Total Synthesis of Ritterazine B
نویسندگان
چکیده
The first total synthesis of the cytotoxic alkaloid ritterazine B is reported. features a unified approach to both steroid subunits, employing titanium-mediated propargylation reaction achieve divergence from common precursor. Other key steps include gold-catalyzed cycloisomerizations that install spiroketals and late stage C-H oxidation incorporate C7' alcohol.
منابع مشابه
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2021
ISSN: ['0002-7863', '1520-5126', '1943-2984']
DOI: https://doi.org/10.1021/jacs.1c01372